Drug interactions
Amantadine + Henbane
Severity: Moderate
Amantadine and Henbane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are centrally active antimuscarinics and can add to amantadine's CNS effects. This may produce confusion, hallucinations, agitation, tachycardia and urinary retention.
What this interaction means in plain words
Amantadine and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central and peripheral anticholinergic effects.
What to do
Avoid combining where possible, especially in older patients; monitor for delirium and anticholinergic toxicity if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Henbane?
MediHelp rates the interaction as moderate. Amantadine and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which are centrally active antimuscarinics and can add to amantadine's CNS effects. This may produce confusion, hallucinations, agitation, tachycardia and urinary retention.
How serious is the interaction between Amantadine and Henbane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in older patients; monitor for delirium and anticholinergic toxicity if both are used.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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