Drug interactions
Amantadine + Influenza virus vaccine quadrivalent intranasal
Severity: Moderate
Amantadine and Influenza virus vaccine quadrivalent intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amantadine has anti-influenza A activity and could suppress replication of the live attenuated vaccine virus, reducing the immune response. This may lead to inadequate protection from the intranasal vaccine.
What this interaction means in plain words
Amantadine and Influenza virus vaccine quadrivalent intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antiviral activity of amantadine may inhibit replication of the live attenuated vaccine virus.
What to do
Use an inactivated injectable influenza vaccine in patients taking amantadine. If the live intranasal vaccine is chosen, follow labeled timing around antiviral therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as moderate. Amantadine and Influenza virus vaccine quadrivalent intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amantadine has anti-influenza A activity and could suppress replication of the live attenuated vaccine virus, reducing the immune response. This may lead to inadequate protection from the intranasal vaccine.
How serious is the interaction between Amantadine and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an inactivated injectable influenza vaccine in patients taking amantadine. If the live intranasal vaccine is chosen, follow labeled timing around antiviral therapy.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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