Drug interactions
Amantadine + Ipratropium-salbutamol
Severity: Minor
Amantadine and Ipratropium-salbutamol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amantadine has anticholinergic properties that may add to those of ipratropium. With inhaled use, systemic exposure to ipratropium is low, so significant effects are uncommon, but dry mouth, urinary retention or confusion may be heightened in susceptible patients.
What this interaction means in plain words
Amantadine and Ipratropium-salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amantadine belongs to Anti Virals; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor older patients for urinary retention, constipation and confusion. Also watch for worsening narrow-angle glaucoma symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Ipratropium-salbutamol?
MediHelp rates the interaction as minor. Amantadine and Ipratropium-salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amantadine has anticholinergic properties that may add to those of ipratropium. With inhaled use, systemic exposure to ipratropium is low, so significant effects are uncommon, but dry mouth, urinary retention or confusion may be heightened in susceptible patients.
How serious is the interaction between Amantadine and Ipratropium-salbutamol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor older patients for urinary retention, constipation and confusion. Also watch for worsening narrow-angle glaucoma symptoms.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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