Drug interactions
Amantadine + Isavuconazonium
Severity: Minor
Amantadine and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active form of isavuconazonium, inhibits OCT2 and may reduce the renal secretion of amantadine. Amantadine levels could rise modestly, increasing CNS adverse effects.
What this interaction means in plain words
Amantadine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amantadine belongs to Anti Virals; Isavuconazonium belongs to Anti Fungals.
Why it happens
Inhibition of OCT2-mediated renal tubular secretion of amantadine.
What to do
Monitor for confusion, hallucinations and dizziness, especially with renal impairment. Reduce the amantadine dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Isavuconazonium?
MediHelp rates the interaction as minor. Amantadine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole, the active form of isavuconazonium, inhibits OCT2 and may reduce the renal secretion of amantadine. Amantadine levels could rise modestly, increasing CNS adverse effects.
How serious is the interaction between Amantadine and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for confusion, hallucinations and dizziness, especially with renal impairment. Reduce the amantadine dose if toxicity develops.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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