Drug interactions
Amantadine + Mefloquine
Severity: Moderate
Amantadine and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amantadine has been associated with QT prolongation and arrhythmia, particularly with renal impairment or other risk factors, and mefloquine may also affect cardiac conduction and QT. Combined use may increase the risk of ventricular arrhythmia, and both can cause neuropsychiatric effects.
What this interaction means in plain words
Amantadine and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation and overlapping CNS toxicity.
What to do
Consider an alternative antimalarial; if both are used, obtain a baseline ECG, correct electrolytes and monitor for palpitations and neuropsychiatric symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Mefloquine?
MediHelp rates the interaction as moderate. Amantadine and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amantadine has been associated with QT prolongation and arrhythmia, particularly with renal impairment or other risk factors, and mefloquine may also affect cardiac conduction and QT. Combined use may increase the risk of ventricular arrhythmia, and both can cause neuropsychiatric effects.
How serious is the interaction between Amantadine and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antimalarial; if both are used, obtain a baseline ECG, correct electrolytes and monitor for palpitations and neuropsychiatric symptoms.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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