Drug interactions
Amantadine + Methamphetamine
Severity: Moderate
Amantadine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs stimulate the CNS, and methamphetamine also has marked sympathomimetic effects. Combined use may cause agitation, insomnia, tremor, tachycardia or raised blood pressure.
What this interaction means in plain words
Amantadine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Methamphetamine belongs to Central Nervous System.
Why it happens
Additive CNS and sympathomimetic stimulation.
What to do
Monitor heart rate, blood pressure and neuropsychiatric symptoms, and reduce the dose of either drug if overstimulation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Methamphetamine?
MediHelp rates the interaction as moderate. Amantadine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs stimulate the CNS, and methamphetamine also has marked sympathomimetic effects. Combined use may cause agitation, insomnia, tremor, tachycardia or raised blood pressure.
How serious is the interaction between Amantadine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and neuropsychiatric symptoms, and reduce the dose of either drug if overstimulation occurs.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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