Drug interactions
Amantadine + Methazolamide
Severity: Minor
Amantadine and Methazolamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methazolamide is a carbonic anhydrase inhibitor that tends to alkalinize the urine rather than acidify it. Alkaline urine lowers amantadine clearance, so levels could rise and cause CNS adverse effects. The effect is likely small.
What this interaction means in plain words
Amantadine and Methazolamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Urinary alkalinization from carbonic anhydrase inhibition may reduce renal clearance of amantadine.
What to do
Monitor for amantadine adverse effects such as confusion, dizziness and hallucinations, particularly in renal impairment. Reduce the amantadine dose if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Methazolamide?
MediHelp rates the interaction as minor. Amantadine and Methazolamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methazolamide is a carbonic anhydrase inhibitor that tends to alkalinize the urine rather than acidify it. Alkaline urine lowers amantadine clearance, so levels could rise and cause CNS adverse effects. The effect is likely small.
How serious is the interaction between Amantadine and Methazolamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for amantadine adverse effects such as confusion, dizziness and hallucinations, particularly in renal impairment. Reduce the amantadine dose if toxicity occurs.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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