Drug interactions
Amantadine + Olopatadine intranasal
Severity: Moderate
Amantadine and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence and amantadine can cause dizziness and confusion. Together they may add to CNS depression and impair psychomotor performance, though systemic exposure from the nasal spray is limited.
What this interaction means in plain words
Amantadine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Warn patients about drowsiness and impaired driving or machinery use. Reduce the olopatadine dose or choose a non-sedating alternative if sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Amantadine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal olopatadine can cause somnolence and amantadine can cause dizziness and confusion. Together they may add to CNS depression and impair psychomotor performance, though systemic exposure from the nasal spray is limited.
How serious is the interaction between Amantadine and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about drowsiness and impaired driving or machinery use. Reduce the olopatadine dose or choose a non-sedating alternative if sedation occurs.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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