Drug interactions
Amantadine + Oxybutynin transdermal
Severity: Moderate
Amantadine and Oxybutynin transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin is absorbed systemically from the patch and has anticholinergic effects that can add to those of amantadine. Confusion, dry mouth, constipation and urinary retention may occur, though the transdermal route produces lower levels of the active metabolite than oral use.
What this interaction means in plain words
Amantadine and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic pharmacodynamic effects.
What to do
Monitor cognition and for urinary retention and constipation, especially in older patients; consider a lower oxybutynin dose or alternative if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Oxybutynin transdermal?
MediHelp rates the interaction as moderate. Amantadine and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxybutynin is absorbed systemically from the patch and has anticholinergic effects that can add to those of amantadine. Confusion, dry mouth, constipation and urinary retention may occur, though the transdermal route produces lower levels of the active metabolite than oral use.
How serious is the interaction between Amantadine and Oxybutynin transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and for urinary retention and constipation, especially in older patients; consider a lower oxybutynin dose or alternative if problems arise.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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