Drug interactions
Amantadine + Propantheline
Severity: Minor
Amantadine and Propantheline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propantheline is a quaternary antimuscarinic that can add to amantadine's anticholinergic effects. This may cause dry mouth, constipation, urinary retention and tachycardia, with confusion less likely because of limited CNS penetration.
What this interaction means in plain words
Amantadine and Propantheline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive peripheral anticholinergic effects.
What to do
Monitor for urinary retention, constipation and tachycardia; reduce the propantheline dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Propantheline?
MediHelp rates the interaction as minor. Amantadine and Propantheline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propantheline is a quaternary antimuscarinic that can add to amantadine's anticholinergic effects. This may cause dry mouth, constipation, urinary retention and tachycardia, with confusion less likely because of limited CNS penetration.
How serious is the interaction between Amantadine and Propantheline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and tachycardia; reduce the propantheline dose if symptoms occur.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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