Drug interactions
Amantadine + Trospium chloride
Severity: Moderate
Amantadine and Trospium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trospium is an antimuscarinic that can add to amantadine's anticholinergic effects, and both are renally eliminated by tubular secretion. This may cause dry mouth, constipation, urinary retention and tachycardia, with less central effect because trospium is a quaternary amine.
What this interaction means in plain words
Amantadine and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic effects, with possible competition for renal tubular secretion.
What to do
Monitor for urinary retention, constipation and confusion, and adjust doses of both drugs in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Trospium chloride?
MediHelp rates the interaction as moderate. Amantadine and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trospium is an antimuscarinic that can add to amantadine's anticholinergic effects, and both are renally eliminated by tubular secretion. This may cause dry mouth, constipation, urinary retention and tachycardia, with less central effect because trospium is a quaternary amine.
How serious is the interaction between Amantadine and Trospium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and confusion, and adjust doses of both drugs in renal impairment.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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