Drug interactions
Amantadine + Umeclidinium bromide
Severity: Minor
Amantadine and Umeclidinium bromide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amantadine has anticholinergic properties, and umeclidinium is an inhaled antimuscarinic. Together they may add to anticholinergic effects such as dry mouth, urinary retention, constipation, blurred vision and confusion, particularly in older patients. Systemic exposure to inhaled umeclidinium is low, so the effect is usually modest.
What this interaction means in plain words
Amantadine and Umeclidinium bromide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for urinary retention, constipation, narrow-angle glaucoma symptoms and confusion, especially in elderly patients or those with prostatic hypertrophy. Reduce or stop one agent if anticholinergic effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Umeclidinium bromide?
MediHelp rates the interaction as minor. Amantadine and Umeclidinium bromide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amantadine has anticholinergic properties, and umeclidinium is an inhaled antimuscarinic. Together they may add to anticholinergic effects such as dry mouth, urinary retention, constipation, blurred vision and confusion, particularly in older patients. Systemic exposure to inhaled umeclidinium is low, so the effect is usually modest.
How serious is the interaction between Amantadine and Umeclidinium bromide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, narrow-angle glaucoma symptoms and confusion, especially in elderly patients or those with prostatic hypertrophy. Reduce or stop one agent if anticholinergic effects emerge.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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