Drug interactions
Amifampridine + Clozapine
Severity: Moderate
Amifampridine and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine carries a dose-related seizure risk, and clozapine itself lowers the seizure threshold in a dose-dependent manner. Combined use may increase the chance of seizures.
What this interaction means in plain words
Amifampridine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Clozapine belongs to Central Nervous System.
Why it happens
Additive lowering of seizure threshold through pharmacodynamic effects.
What to do
Use the lowest effective doses and monitor for seizure activity, particularly with higher clozapine doses or a history of epilepsy. Consider an alternative if seizures occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Clozapine?
MediHelp rates the interaction as moderate. Amifampridine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine carries a dose-related seizure risk, and clozapine itself lowers the seizure threshold in a dose-dependent manner. Combined use may increase the chance of seizures.
How serious is the interaction between Amifampridine and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for seizure activity, particularly with higher clozapine doses or a history of epilepsy. Consider an alternative if seizures occur.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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