Drug interactions
Amifampridine + Erythromycin
Severity: Moderate
Amifampridine and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine carries a dose-related seizure risk. Erythromycin has been reported to lower seizure threshold in some settings, so combined use might add to this risk, although the evidence is limited.
What this interaction means in plain words
Amifampridine and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Erythromycin belongs to Anti Bacterial.
Why it happens
Possible additive pharmacodynamic lowering of seizure threshold; not firmly established.
What to do
Monitor for neurological symptoms and seizures, and use the lowest effective amifampridine dose. Consider a different antibiotic class in patients with seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Erythromycin?
MediHelp rates the interaction as moderate. Amifampridine and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine carries a dose-related seizure risk. Erythromycin has been reported to lower seizure threshold in some settings, so combined use might add to this risk, although the evidence is limited.
How serious is the interaction between Amifampridine and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurological symptoms and seizures, and use the lowest effective amifampridine dose. Consider a different antibiotic class in patients with seizure history.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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