Drug interactions
domperidone + erythromycin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
QT prolongation/arrhythmia risk.
Mechanism of action
CYP3A4 inhibition + additive QT.
Clinical management
Avoid; monitor ECG if unavoidable.
Drug reference
References
Frequently asked questions
Can I take domperidone with erythromycin?
The interaction is rated: Major. QT prolongation/arrhythmia risk.
How serious is the interaction between domperidone and erythromycin?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between domperidone and erythromycin managed?
Avoid; monitor ECG if unavoidable.
Why do domperidone and erythromycin interact?
CYP3A4 inhibition + additive QT.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.