Drug interactions
Amifampridine + Meropenem
Severity: Moderate
Amifampridine and Meropenem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower the seizure threshold, and carbapenems such as meropenem have been associated with seizures, particularly in renal impairment or CNS disease. Combining them may raise the risk of seizures in patients taking amifampridine.
What this interaction means in plain words
Amifampridine and Meropenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Meropenem belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic lowering of the seizure threshold.
What to do
Consider an alternative antibiotic with lower seizure liability in patients with a seizure history or renal impairment. If combined, adjust meropenem for renal function and monitor for neurological signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meropenem
- Meropenem + Valproic acid Contraindicated
- Meropenem + Typhoid vaccine live Major
- Cholera vaccine + Meropenem Moderate
- Meropenem + Microbiota Moderate
- Meropenem + Probenecid Moderate
- Meropenem + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Meropenem?
MediHelp rates the interaction as moderate. Amifampridine and Meropenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower the seizure threshold, and carbapenems such as meropenem have been associated with seizures, particularly in renal impairment or CNS disease. Combining them may raise the risk of seizures in patients taking amifampridine.
How serious is the interaction between Amifampridine and Meropenem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic with lower seizure liability in patients with a seizure history or renal impairment. If combined, adjust meropenem for renal function and monitor for neurological signs.
What other medicines interact with Meropenem?
MediHelp also lists interactions of Meropenem with, for example, Valproic acid, Typhoid vaccine live, Cholera vaccine. The full list is on the Meropenem page.
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