Drug interactions
Meropenem + Typhoid vaccine live
Severity: Major
Meropenem and Typhoid vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi in the gut. Meropenem is highly active against Salmonella and may reduce vaccine viability and the immune response.
What this interaction means in plain words
Meropenem and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Antibacterial activity inhibits the live attenuated Salmonella strain, reducing immunogenicity.
What to do
Give live oral typhoid vaccine at least 3 days after the last meropenem dose, or vaccinate beforehand. Use the inactivated parenteral vaccine if timing cannot be separated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meropenem
- Meropenem + Valproic acid Contraindicated
- Amifampridine + Meropenem Moderate
- Cholera vaccine + Meropenem Moderate
- Meropenem + Microbiota Moderate
- Meropenem + Probenecid Moderate
- Meropenem + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Meropenem with Typhoid vaccine live?
MediHelp rates the interaction as major. Meropenem and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi in the gut. Meropenem is highly active against Salmonella and may reduce vaccine viability and the immune response.
How serious is the interaction between Meropenem and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live oral typhoid vaccine at least 3 days after the last meropenem dose, or vaccinate beforehand. Use the inactivated parenteral vaccine if timing cannot be separated.
What other medicines interact with Meropenem?
MediHelp also lists interactions of Meropenem with, for example, Valproic acid, Amifampridine, Cholera vaccine. The full list is on the Meropenem page.
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