Drug interactions
Amifampridine + Ofloxacin
Severity: Moderate
Amifampridine and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine dose-dependently lowers seizure threshold, and fluoroquinolones such as ofloxacin can also provoke seizures. Using them together may raise the risk of convulsions, especially in patients with renal impairment or a seizure history.
What this interaction means in plain words
Amifampridine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive lowering of seizure threshold through pharmacodynamic effects on the CNS.
What to do
Prefer a non-fluoroquinolone antibiotic where possible. If the combination is needed, monitor for neurological symptoms and review the amifampridine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Ofloxacin?
MediHelp rates the interaction as moderate. Amifampridine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine dose-dependently lowers seizure threshold, and fluoroquinolones such as ofloxacin can also provoke seizures. Using them together may raise the risk of convulsions, especially in patients with renal impairment or a seizure history.
How serious is the interaction between Amifampridine and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-fluoroquinolone antibiotic where possible. If the combination is needed, monitor for neurological symptoms and review the amifampridine dose.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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