Drug interactions
Amifostine + Asenapine
Severity: Moderate
Amifostine and Asenapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension through alpha-1 blockade, and amifostine commonly causes hypotension during infusion. Together they may cause more severe blood pressure drops.
What this interaction means in plain words
Amifostine and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Asenapine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects (alpha-1 adrenergic blockade plus amifostine-induced vasodilation).
What to do
Monitor blood pressure before and during amifostine infusion. At chemotherapeutic doses, consider withholding asenapine for 24 hours beforehand if clinically feasible, and ensure good hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Asenapine?
MediHelp rates the interaction as moderate. Amifostine and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension through alpha-1 blockade, and amifostine commonly causes hypotension during infusion. Together they may cause more severe blood pressure drops.
How serious is the interaction between Amifostine and Asenapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion. At chemotherapeutic doses, consider withholding asenapine for 24 hours beforehand if clinically feasible, and ensure good hydration.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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