Drug reference
asenapine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Anti Psychotic (atypical))
Mechanism of action
Mechanism of action unknown; efficacy thought to be mediated via combined antagonist activity at dopamine D2 and serotonin type 2 (5-HT2) receptors
Common side effects
- Insomnia
- Dizziness
- Somnolence
- Headache
- Weight gain
- Oral paraesthesia
- Extrapyramidal symptom
Known interactions (6)
- asenapine + pimozide Contraindicated
- asenapine + thioridazine Contraindicated
- amisulpride + asenapine Major
- asenapine + dronedarone Major
- asenapine + fluconazole Moderate
- asenapine + posaconazole Moderate
Related conditions
Frequently asked questions
What drug class is asenapine?
asenapine belongs to: Central Nervous System.
How does asenapine work?
Mechanism of action unknown; efficacy thought to be mediated via combined antagonist activity at dopamine D2 and serotonin type 2 (5-HT2) receptors
What are the common side effects of asenapine?
Insomnia, Dizziness, Somnolence, Headache, Weight gain, Oral paraesthesia, Extrapyramidal symptom
Which drugs interact with asenapine?
pimozide, thioridazine, amisulpride, dronedarone, fluconazole, posaconazole
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