Drug interactions
Amifostine + Brimonidine
Severity: Minor
Amifostine and Brimonidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and agents that lower blood pressure can worsen it. Brimonidine given as eye drops has limited systemic absorption but can lower blood pressure in some patients.
What this interaction means in plain words
Amifostine and Brimonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amifostine belongs to Miscellaneous; Brimonidine belongs to Miscellaneous.
Why it happens
Additive hypotensive effects from alpha-2 agonism (brimonidine) and amifostine.
What to do
Monitor blood pressure during amifostine infusion in patients using brimonidine. Follow the amifostine labeling on withholding antihypertensives at chemotherapeutic doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Brimonidine?
MediHelp rates the interaction as minor. Amifostine and Brimonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amifostine commonly causes hypotension, and agents that lower blood pressure can worsen it. Brimonidine given as eye drops has limited systemic absorption but can lower blood pressure in some patients.
How serious is the interaction between Amifostine and Brimonidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during amifostine infusion in patients using brimonidine. Follow the amifostine labeling on withholding antihypertensives at chemotherapeutic doses.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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