Drug interactions
Amikacin + Aspirin / citric acid / sodium bicarbonate
Severity: Moderate
Amikacin and Aspirin / citric acid / sodium bicarbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This effervescent product delivers analgesic doses of aspirin that can reduce renal perfusion and may raise aminoglycoside levels. High salicylate exposure can also add to ototoxicity.
What this interaction means in plain words
Amikacin and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal clearance of amikacin through prostaglandin inhibition, with additive ototoxic potential at high salicylate doses.
What to do
Monitor renal function and amikacin levels, and adjust the amikacin dose accordingly. Prefer paracetamol in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Aspirin / citric acid / sodium bicarbonate?
MediHelp rates the interaction as moderate. Amikacin and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This effervescent product delivers analgesic doses of aspirin that can reduce renal perfusion and may raise aminoglycoside levels. High salicylate exposure can also add to ototoxicity.
How serious is the interaction between Amikacin and Aspirin / citric acid / sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and amikacin levels, and adjust the amikacin dose accordingly. Prefer paracetamol in patients with renal impairment.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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