Drug interactions
Amikacin + Aspirin rectal
Severity: Moderate
Amikacin and Aspirin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and can reduce renal perfusion. It may raise amikacin levels and add to ototoxicity, particularly in neonates or patients with renal impairment.
What this interaction means in plain words
Amikacin and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal clearance of amikacin through prostaglandin inhibition, with additive ototoxic potential at high salicylate doses.
What to do
Monitor renal function and amikacin levels, and adjust the amikacin dose accordingly. Choose an alternative antipyretic or analgesic in neonates or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Aspirin rectal?
MediHelp rates the interaction as moderate. Amikacin and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and can reduce renal perfusion. It may raise amikacin levels and add to ototoxicity, particularly in neonates or patients with renal impairment.
How serious is the interaction between Amikacin and Aspirin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and amikacin levels, and adjust the amikacin dose accordingly. Choose an alternative antipyretic or analgesic in neonates or renal impairment.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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