Drug interactions
Amikacin + Bcg vaccine live
Severity: Moderate
Amikacin and Bcg vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amikacin is active against mycobacteria and could reduce the viability of live BCG, lowering the immune response. Vaccination during antimycobacterial therapy may therefore be ineffective.
What this interaction means in plain words
Amikacin and Bcg vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antimycobacterial activity inhibits the live attenuated BCG organism, reducing its replication and immunogenicity.
What to do
Defer BCG vaccination until amikacin therapy is complete and reassess the need for vaccination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Bcg vaccine live?
MediHelp rates the interaction as moderate. Amikacin and Bcg vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amikacin is active against mycobacteria and could reduce the viability of live BCG, lowering the immune response. Vaccination during antimycobacterial therapy may therefore be ineffective.
How serious is the interaction between Amikacin and Bcg vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer BCG vaccination until amikacin therapy is complete and reassess the need for vaccination.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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