Drug interactions
Amikacin + Capreomycin
Severity: Major
Amikacin and Capreomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are injectable agents that can damage the kidneys and the inner ear. Using them together adds to the risk of kidney injury, hearing loss, vestibular damage and neuromuscular blockade.
What this interaction means in plain words
Amikacin and Capreomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, ototoxicity and neuromuscular blocking effects from two drugs with overlapping toxicities.
What to do
Avoid the combination where an alternative exists. If it is unavoidable, monitor serum creatinine, drug levels and audiometry or vestibular function regularly, and adjust doses to renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Capreomycin?
MediHelp rates the interaction as major. Amikacin and Capreomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are injectable agents that can damage the kidneys and the inner ear. Using them together adds to the risk of kidney injury, hearing loss, vestibular damage and neuromuscular blockade.
How serious is the interaction between Amikacin and Capreomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If it is unavoidable, monitor serum creatinine, drug levels and audiometry or vestibular function regularly, and adjust doses to renal function.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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