Drug interactions
Amikacin + Ceftaroline
Severity: Moderate
Amikacin and Ceftaroline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amikacin is nephrotoxic and ototoxic, and combining it with a cephalosporin may increase renal injury in vulnerable patients. Ceftaroline is renally cleared, so declining renal function raises exposure to it.
What this interaction means in plain words
Amikacin and Ceftaroline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive nephrotoxicity, and reduced clearance of both drugs when renal function falls.
What to do
Monitor creatinine and amikacin concentrations, and adjust doses for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Ceftaroline?
MediHelp rates the interaction as moderate. Amikacin and Ceftaroline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amikacin is nephrotoxic and ototoxic, and combining it with a cephalosporin may increase renal injury in vulnerable patients. Ceftaroline is renally cleared, so declining renal function raises exposure to it.
How serious is the interaction between Amikacin and Ceftaroline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine and amikacin concentrations, and adjust doses for renal function.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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