Drug interactions
Amikacin + Ceftibuten
Severity: Moderate
Amikacin and Ceftibuten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycoside nephrotoxicity may be modestly increased by cephalosporins, particularly with pre-existing renal impairment. Ceftibuten is renally eliminated, so any decline in kidney function raises its exposure.
What this interaction means in plain words
Amikacin and Ceftibuten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive renal tubular toxicity.
What to do
Monitor renal function and amikacin concentrations, and adjust doses to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Ceftibuten?
MediHelp rates the interaction as moderate. Amikacin and Ceftibuten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycoside nephrotoxicity may be modestly increased by cephalosporins, particularly with pre-existing renal impairment. Ceftibuten is renally eliminated, so any decline in kidney function raises its exposure.
How serious is the interaction between Amikacin and Ceftibuten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and amikacin concentrations, and adjust doses to creatinine clearance.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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