Drug interactions
Amikacin + Ceftizoxime
Severity: Moderate
Amikacin and Ceftizoxime: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using an aminoglycoside with a cephalosporin may increase the chance of kidney injury, especially in older or dehydrated patients or those with renal disease. Aminoglycoside ototoxicity is an additional concern with prolonged courses.
What this interaction means in plain words
Amikacin and Ceftizoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive nephrotoxicity.
What to do
Monitor serum creatinine and amikacin levels, and adjust doses for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Ceftizoxime?
MediHelp rates the interaction as moderate. Amikacin and Ceftizoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using an aminoglycoside with a cephalosporin may increase the chance of kidney injury, especially in older or dehydrated patients or those with renal disease. Aminoglycoside ototoxicity is an additional concern with prolonged courses.
How serious is the interaction between Amikacin and Ceftizoxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels, and adjust doses for renal function.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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