Drug interactions
Amikacin + Ceftolozane / tazobactam
Severity: Moderate
Amikacin and Ceftolozane / tazobactam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pair may be used together for resistant Pseudomonas infection, but aminoglycoside nephrotoxicity and ototoxicity may be increased by concurrent cephalosporin exposure. Both drugs are renally cleared, so renal injury increases exposure to each.
What this interaction means in plain words
Amikacin and Ceftolozane / tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive nephrotoxicity with shared renal elimination.
What to do
Monitor serum creatinine and amikacin levels, and adjust doses for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Ceftolozane / tazobactam?
MediHelp rates the interaction as moderate. Amikacin and Ceftolozane / tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The pair may be used together for resistant Pseudomonas infection, but aminoglycoside nephrotoxicity and ototoxicity may be increased by concurrent cephalosporin exposure. Both drugs are renally cleared, so renal injury increases exposure to each.
How serious is the interaction between Amikacin and Ceftolozane / tazobactam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels, and adjust doses for renal function.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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