Drug interactions
Amikacin + Conjugated estrogens
Severity: Minor
Amikacin and Conjugated estrogens: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics that disturb gut flora were theorized to reduce estrogen recycling, but amikacin is poorly absorbed orally and gives little systemic effect when injected. Any reduction in estrogen effect is unlikely to matter clinically.
What this interaction means in plain words
Amikacin and Conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in enterohepatic recirculation of estrogens through changes in intestinal flora.
What to do
No routine action is needed. Review symptom control if prolonged oral antibiotic therapy is given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Conjugated estrogens?
MediHelp rates the interaction as minor. Amikacin and Conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics that disturb gut flora were theorized to reduce estrogen recycling, but amikacin is poorly absorbed orally and gives little systemic effect when injected. Any reduction in estrogen effect is unlikely to matter clinically.
How serious is the interaction between Amikacin and Conjugated estrogens?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Review symptom control if prolonged oral antibiotic therapy is given.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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