Drug interactions
Amikacin + Cyclosporine
Severity: Major
Amikacin and Cyclosporine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and their combination increases the incidence of acute kidney injury. Reduced renal function can in turn raise aminoglycoside concentrations and ototoxicity risk.
What this interaction means in plain words
Amikacin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity via tubular injury and cyclosporine-induced renal vasoconstriction.
What to do
Avoid if an alternative antibiotic exists. If used, monitor serum creatinine, amikacin trough levels and cyclosporine concentrations frequently and adjust doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Cyclosporine?
MediHelp rates the interaction as major. Amikacin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and their combination increases the incidence of acute kidney injury. Reduced renal function can in turn raise aminoglycoside concentrations and ototoxicity risk.
How serious is the interaction between Amikacin and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antibiotic exists. If used, monitor serum creatinine, amikacin trough levels and cyclosporine concentrations frequently and adjust doses.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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