Drug interactions
Amikacin + Daxibotulinumtoxina
Severity: Moderate
Amikacin and Daxibotulinumtoxina: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides impair neuromuscular transmission and may potentiate botulinum toxin. This may cause excessive or spreading muscle weakness, including swallowing and breathing difficulty.
What this interaction means in plain words
Amikacin and Daxibotulinumtoxina can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive neuromuscular blockade, as aminoglycosides reduce presynaptic acetylcholine release while botulinum toxin blocks its release.
What to do
Avoid giving amikacin around the time of botulinum toxin injection where possible. If both are needed, monitor for generalized weakness, dysphagia and respiratory compromise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Daxibotulinumtoxina?
MediHelp rates the interaction as moderate. Amikacin and Daxibotulinumtoxina can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides impair neuromuscular transmission and may potentiate botulinum toxin. This may cause excessive or spreading muscle weakness, including swallowing and breathing difficulty.
How serious is the interaction between Amikacin and Daxibotulinumtoxina?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving amikacin around the time of botulinum toxin injection where possible. If both are needed, monitor for generalized weakness, dysphagia and respiratory compromise.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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