Drug interactions
Amikacin + Dienogest / estradiol valerate
Severity: Minor
Amikacin and Dienogest / estradiol valerate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics were once thought to reduce hormonal contraceptive efficacy by disturbing gut flora, though evidence for non-rifamycin antibiotics is weak. Amikacin is poorly absorbed orally, so the risk of contraceptive failure is very low.
What this interaction means in plain words
Amikacin and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in enterohepatic recirculation of estrogen through changes in intestinal flora.
What to do
No routine change is needed. Advise reporting breakthrough bleeding or vomiting and diarrhea, which may reduce hormone absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amikacin and Dienogest / estradiol valerate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Dienogest / estradiol valerate?
MediHelp rates the interaction as minor. Amikacin and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics were once thought to reduce hormonal contraceptive efficacy by disturbing gut flora, though evidence for non-rifamycin antibiotics is weak. Amikacin is poorly absorbed orally, so the risk of contraceptive failure is very low.
How serious is the interaction between Amikacin and Dienogest / estradiol valerate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise reporting breakthrough bleeding or vomiting and diarrhea, which may reduce hormone absorption.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
