Drug interactions
Amikacin + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Major
Amikacin and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amikacin is nephrotoxic, and tenofovir DF can cause proximal tubular injury. Cobicistat also raises serum creatinine by blocking tubular secretion, which can obscure true renal decline. Combined use raises the risk of acute kidney injury.
What this interaction means in plain words
Amikacin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, with cobicistat-related creatinine elevation complicating renal assessment.
What to do
Avoid concurrent use where possible, or monitor serum creatinine, phosphate and urinalysis closely and measure amikacin levels. Stop the combination if renal function worsens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Amikacin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amikacin is nephrotoxic, and tenofovir DF can cause proximal tubular injury. Cobicistat also raises serum creatinine by blocking tubular secretion, which can obscure true renal decline. Combined use raises the risk of acute kidney injury.
How serious is the interaction between Amikacin and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, or monitor serum creatinine, phosphate and urinalysis closely and measure amikacin levels. Stop the combination if renal function worsens.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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