Drug interactions
Amikacin + Fenoprofen
Severity: Moderate
Amikacin and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce aminoglycoside clearance, raising amikacin levels and the risk of nephrotoxicity and ototoxicity. This has been described mainly in neonates treated with indomethacin or ibuprofen, and fenoprofen is expected to behave similarly via renal effects.
What this interaction means in plain words
Amikacin and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Fenoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and glomerular filtration, decreasing aminoglycoside excretion.
What to do
Monitor renal function and amikacin serum concentrations, adjusting the dose as needed. Avoid combining in neonates or patients with renal impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Fenoprofen?
MediHelp rates the interaction as moderate. Amikacin and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce aminoglycoside clearance, raising amikacin levels and the risk of nephrotoxicity and ototoxicity. This has been described mainly in neonates treated with indomethacin or ibuprofen, and fenoprofen is expected to behave similarly via renal effects.
How serious is the interaction between Amikacin and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and amikacin serum concentrations, adjusting the dose as needed. Avoid combining in neonates or patients with renal impairment where possible.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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