Drug interactions
Amikacin + Fosphenytoin
Severity: Minor
Amikacin and Fosphenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin may induce P-glycoprotein, but amikacin is eliminated mainly by glomerular filtration and is given parenterally, so a meaningful drop in levels is not expected. No clinically significant effect has been documented.
What this interaction means in plain words
Amikacin and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amikacin belongs to Anti Bacterial; Fosphenytoin belongs to Central Nervous System.
Why it happens
Theoretical P-glycoprotein induction by phenytoin; relevance for amikacin is not established.
What to do
No specific action is needed beyond routine amikacin level monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Amikacin with Fosphenytoin?
MediHelp rates the interaction as minor. Amikacin and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin may induce P-glycoprotein, but amikacin is eliminated mainly by glomerular filtration and is given parenterally, so a meaningful drop in levels is not expected. No clinically significant effect has been documented.
How serious is the interaction between Amikacin and Fosphenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine amikacin level monitoring.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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