Drug interactions
Amikacin + Ioversol
Severity: Major
Amikacin and Ioversol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ioversol is an iodinated contrast agent that can cause contrast-associated kidney injury. With amikacin, the risk of nephrotoxicity rises, and reduced clearance can increase aminoglycoside toxicity including ototoxicity.
What this interaction means in plain words
Amikacin and Ioversol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, with reduced renal elimination of amikacin.
What to do
Hydrate the patient and delay contrast if feasible in those with renal impairment. Monitor serum creatinine and amikacin levels after contrast.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Ioversol?
MediHelp rates the interaction as major. Amikacin and Ioversol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ioversol is an iodinated contrast agent that can cause contrast-associated kidney injury. With amikacin, the risk of nephrotoxicity rises, and reduced clearance can increase aminoglycoside toxicity including ototoxicity.
How serious is the interaction between Amikacin and Ioversol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hydrate the patient and delay contrast if feasible in those with renal impairment. Monitor serum creatinine and amikacin levels after contrast.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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