Drug interactions
Amikacin + Ketorolac intranasal
Severity: Moderate
Amikacin and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is absorbed systemically after intranasal use and is a potent NSAID with notable renal effects. It can reduce renal perfusion, raise amikacin levels and increase the risk of kidney injury and ototoxicity.
What this interaction means in plain words
Amikacin and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal blood flow decreases aminoglycoside clearance, with additive nephrotoxicity.
What to do
Monitor serum creatinine and amikacin levels, and adjust the amikacin dose accordingly. Avoid ketorolac in patients with renal impairment or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Amikacin and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is absorbed systemically after intranasal use and is a potent NSAID with notable renal effects. It can reduce renal perfusion, raise amikacin levels and increase the risk of kidney injury and ototoxicity.
How serious is the interaction between Amikacin and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels, and adjust the amikacin dose accordingly. Avoid ketorolac in patients with renal impairment or dehydration.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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