Drug interactions
Amikacin + Ketorolac
Severity: Moderate
Amikacin and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and raise aminoglycoside levels, particularly in neonates, and both drugs are nephrotoxic. This may increase the risk of kidney injury and aminoglycoside toxicity.
What this interaction means in plain words
Amikacin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Ketorolac belongs to Musculoskeletal.
Why it happens
NSAID-related reduction in renal prostaglandins and glomerular filtration decreases aminoglycoside clearance, with additive nephrotoxicity.
What to do
Monitor serum creatinine and amikacin trough levels and adjust dose accordingly. Avoid ketorolac in neonates and patients with renal impairment or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Ketorolac?
MediHelp rates the interaction as moderate. Amikacin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and raise aminoglycoside levels, particularly in neonates, and both drugs are nephrotoxic. This may increase the risk of kidney injury and aminoglycoside toxicity.
How serious is the interaction between Amikacin and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin trough levels and adjust dose accordingly. Avoid ketorolac in neonates and patients with renal impairment or dehydration.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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