Drug interactions
Amikacin + Magnesium chloride
Severity: Moderate
Amikacin and Magnesium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia with prolonged use. Parenteral magnesium may also add to aminoglycoside neuromuscular blockade.
What this interaction means in plain words
Amikacin and Magnesium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aminoglycoside-induced renal tubular magnesium loss, and additive neuromuscular blocking effects of magnesium.
What to do
Monitor serum magnesium, calcium and potassium during amikacin therapy and replace as needed. Watch for muscle weakness when giving parenteral magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Magnesium chloride?
MediHelp rates the interaction as moderate. Amikacin and Magnesium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia with prolonged use. Parenteral magnesium may also add to aminoglycoside neuromuscular blockade.
How serious is the interaction between Amikacin and Magnesium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium, calcium and potassium during amikacin therapy and replace as needed. Watch for muscle weakness when giving parenteral magnesium.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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