Drug interactions
Amikacin + Magnesium sulfate
Severity: Moderate
Amikacin and Magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can cause renal magnesium wasting, and intravenous magnesium sulfate has neuromuscular blocking effects that add to those of aminoglycosides. This may cause muscle weakness or respiratory depression.
What this interaction means in plain words
Amikacin and Magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive neuromuscular blockade, plus aminoglycoside-induced renal magnesium loss.
What to do
Monitor respiratory function and muscle strength when given together, and check serum magnesium and calcium. Give magnesium replacement as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Magnesium sulfate?
MediHelp rates the interaction as moderate. Amikacin and Magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can cause renal magnesium wasting, and intravenous magnesium sulfate has neuromuscular blocking effects that add to those of aminoglycosides. This may cause muscle weakness or respiratory depression.
How serious is the interaction between Amikacin and Magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory function and muscle strength when given together, and check serum magnesium and calcium. Give magnesium replacement as needed.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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