Drug interactions
Amikacin + Magnesium supplement
Severity: Moderate
Amikacin and Magnesium supplement: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides and magnesium both depress neuromuscular transmission. Together they may produce muscle weakness and, in severe cases, respiratory depression, especially with parenteral magnesium or high doses.
What this interaction means in plain words
Amikacin and Magnesium supplement can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic effects.
What to do
Monitor for weakness and respiratory function, particularly with intravenous magnesium or renal impairment. Check serum magnesium and avoid unnecessary magnesium doses during aminoglycoside therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amikacin and Magnesium supplement, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Magnesium supplement?
MediHelp rates the interaction as moderate. Amikacin and Magnesium supplement can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides and magnesium both depress neuromuscular transmission. Together they may produce muscle weakness and, in severe cases, respiratory depression, especially with parenteral magnesium or high doses.
How serious is the interaction between Amikacin and Magnesium supplement?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for weakness and respiratory function, particularly with intravenous magnesium or renal impairment. Check serum magnesium and avoid unnecessary magnesium doses during aminoglycoside therapy.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
