Drug interactions
Amikacin + Meclofenamate
Severity: Moderate
Amikacin and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal perfusion and raise aminoglycoside levels, as described mainly in neonates. The combination may also add to kidney injury risk.
What this interaction means in plain words
Amikacin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal blood flow decreases aminoglycoside clearance.
What to do
Monitor serum creatinine and amikacin levels, and adjust the amikacin dose accordingly. Avoid in neonates and in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Meclofenamate?
MediHelp rates the interaction as moderate. Amikacin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal perfusion and raise aminoglycoside levels, as described mainly in neonates. The combination may also add to kidney injury risk.
How serious is the interaction between Amikacin and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels, and adjust the amikacin dose accordingly. Avoid in neonates and in patients with renal impairment.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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