Drug interactions
Amikacin + Methoxyflurane
Severity: Major
Amikacin and Methoxyflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane releases fluoride during metabolism and is nephrotoxic at higher exposures. Combined with amikacin, which is itself nephrotoxic and ototoxic, the risk of acute kidney injury is increased.
What this interaction means in plain words
Amikacin and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from aminoglycoside tubular accumulation and fluoride-mediated renal tubular injury.
What to do
Avoid the combination where possible, especially with anesthetic doses of methoxyflurane. If unavoidable, monitor serum creatinine, urine output and aminoglycoside levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Methoxyflurane?
MediHelp rates the interaction as major. Amikacin and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methoxyflurane releases fluoride during metabolism and is nephrotoxic at higher exposures. Combined with amikacin, which is itself nephrotoxic and ototoxic, the risk of acute kidney injury is increased.
How serious is the interaction between Amikacin and Methoxyflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially with anesthetic doses of methoxyflurane. If unavoidable, monitor serum creatinine, urine output and aminoglycoside levels.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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