Drug interactions
Amikacin + Microbiota
Severity: Moderate
Amikacin and Microbiota: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral microbiota products contain live bacterial spores that must colonize the gut. Systemic amikacin has limited gut exposure, so the effect is much less certain than with oral antibiotics, but antibacterial activity could still reduce engraftment.
What this interaction means in plain words
Amikacin and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may reduce viability or colonization of the administered bacterial spores.
What to do
Complete the antibiotic course and allow the interval stated in the product labeling (a few days) before giving the microbiota product.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Microbiota?
MediHelp rates the interaction as moderate. Amikacin and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral microbiota products contain live bacterial spores that must colonize the gut. Systemic amikacin has limited gut exposure, so the effect is much less certain than with oral antibiotics, but antibacterial activity could still reduce engraftment.
How serious is the interaction between Amikacin and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the antibiotic course and allow the interval stated in the product labeling (a few days) before giving the microbiota product.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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