Drug interactions
Amikacin + Neomycin po
Severity: Major
Amikacin and Neomycin po: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic amikacin combined with oral neomycin adds aminoglycoside exposure, particularly if neomycin absorption rises with damaged bowel mucosa or reduced renal function. This increases the risk of nephrotoxicity, ototoxicity and neuromuscular blockade.
What this interaction means in plain words
Amikacin and Neomycin po can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive aminoglycoside toxicity to the kidney, cochlea and vestibular system.
What to do
Avoid concurrent use where possible; if unavoidable, monitor renal function and amikacin levels and assess hearing and balance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Neomycin po?
MediHelp rates the interaction as major. Amikacin and Neomycin po can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic amikacin combined with oral neomycin adds aminoglycoside exposure, particularly if neomycin absorption rises with damaged bowel mucosa or reduced renal function. This increases the risk of nephrotoxicity, ototoxicity and neuromuscular blockade.
How serious is the interaction between Amikacin and Neomycin po?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if unavoidable, monitor renal function and amikacin levels and assess hearing and balance.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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