Drug interactions
Amikacin + Parecoxib
Severity: Moderate
Amikacin and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib can reduce renal prostaglandin-dependent perfusion and lower aminoglycoside clearance. This can raise amikacin concentrations and the risk of nephrotoxicity and ototoxicity, particularly in neonates and in patients with renal impairment.
What this interaction means in plain words
Amikacin and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal blood flow and glomerular filtration from cyclooxygenase-2 inhibition decreases renal elimination of amikacin.
What to do
Monitor serum creatinine and amikacin trough levels, and adjust the amikacin dose accordingly. In preterm infants or patients with renal impairment, avoid the combination where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Parecoxib?
MediHelp rates the interaction as moderate. Amikacin and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib can reduce renal prostaglandin-dependent perfusion and lower aminoglycoside clearance. This can raise amikacin concentrations and the risk of nephrotoxicity and ototoxicity, particularly in neonates and in patients with renal impairment.
How serious is the interaction between Amikacin and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin trough levels, and adjust the amikacin dose accordingly. In preterm infants or patients with renal impairment, avoid the combination where possible.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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