Drug interactions
Amikacin + Salicylates
Severity: Moderate
Amikacin and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can reduce renal perfusion and may reduce aminoglycoside clearance, and both drug classes have ototoxic and nephrotoxic potential. Concurrent use may increase the risk of kidney injury and hearing or vestibular damage, especially in neonates and patients with renal impairment.
What this interaction means in plain words
Amikacin and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Decreased renal clearance of amikacin combined with additive nephrotoxic and ototoxic effects.
What to do
Monitor renal function and amikacin serum concentrations, and adjust the dose as needed. Consider using a non-salicylate analgesic where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Salicylates?
MediHelp rates the interaction as moderate. Amikacin and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates can reduce renal perfusion and may reduce aminoglycoside clearance, and both drug classes have ototoxic and nephrotoxic potential. Concurrent use may increase the risk of kidney injury and hearing or vestibular damage, especially in neonates and patients with renal impairment.
How serious is the interaction between Amikacin and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and amikacin serum concentrations, and adjust the dose as needed. Consider using a non-salicylate analgesic where feasible.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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