Drug interactions
Amikacin + Salsalate
Severity: Moderate
Amikacin and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID that may reduce renal prostaglandin-mediated perfusion and slow aminoglycoside elimination. Amikacin exposure and the risk of nephrotoxicity and ototoxicity may rise, especially in neonates or renal impairment.
What this interaction means in plain words
Amikacin and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal clearance of amikacin due to prostaglandin inhibition, with additive nephrotoxic and ototoxic potential.
What to do
Monitor serum creatinine and amikacin trough levels during co-therapy. Prefer an alternative analgesic in patients with reduced kidney function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Salsalate?
MediHelp rates the interaction as moderate. Amikacin and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID that may reduce renal prostaglandin-mediated perfusion and slow aminoglycoside elimination. Amikacin exposure and the risk of nephrotoxicity and ototoxicity may rise, especially in neonates or renal impairment.
How serious is the interaction between Amikacin and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin trough levels during co-therapy. Prefer an alternative analgesic in patients with reduced kidney function.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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