Drug interactions
Amikacin + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Amikacin and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium picosulfate requires conversion to its active form by colonic bacteria, and antibacterials can reduce this. Oral amikacin could therefore blunt bowel cleansing, but parenteral amikacin has little effect on colonic flora.
What this interaction means in plain words
Amikacin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Suppression of colonic bacteria needed to activate picosulfate, mainly with oral antibacterial exposure.
What to do
If bowel preparation quality is a concern, confirm adequate cleansing before colonoscopy. Consider timing or an alternative preparation if oral amikacin is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Amikacin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate requires conversion to its active form by colonic bacteria, and antibacterials can reduce this. Oral amikacin could therefore blunt bowel cleansing, but parenteral amikacin has little effect on colonic flora.
How serious is the interaction between Amikacin and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If bowel preparation quality is a concern, confirm adequate cleansing before colonoscopy. Consider timing or an alternative preparation if oral amikacin is used.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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